- HOME >
- For Researchers >
- Product Search >
- Search Result >
- #76101 - 76103 LipoSEARCH (Lipoprotein Profiling Service)
Product Search
#76101 - 76103 LipoSEARCH (Lipoprotein Profiling Service)
- Intended Use:
- Lipoprotein Profiling Service for Research
- Sample Types:
- Human, Mouse, Rat, Others
- Package Size1:
- Available from 1 sample
Product Overview
Product Overview
Product Code | 7610X |
---|---|
Product Name | LipoSEARCH (Lipoprotein Profiling Service) |
Maker Name | Immuno-Biological Laboratories Co., Ltd. |
Intended Use | Lipoprotein Profiling Service for Research |
Species | Human, Mouse, Rat, Others |
Package Size 1 | Available from 1 sample |
Remarks1 | Method: GP-HPLC Sample Type: Serum, EDTA Plasma, Citrated Plasma, etc. ✔ This service is provided in Japan. ✔ The samples should be shipped out to Japan. ✔ The shipping cost is covered by sender.(Either FedEx or World Courier) |
Product Description
Product Description
Detaied & Accurate
LipoSEARCH is a patented lipoprotein profiling service based on a Gel Permeation HPLC.What kind of data can I get?
✔ Both Cholesterol (Cho) and Triglyceride (TG).
✔ 4 major (CM, VLDL, LDL and HDL) + 20 sub-classes by size.
✔ Particle Size and Particle Number (PN)
What is the remarkable feature?
✔ Accurate and Detailed
✔ Only 45μL (Human)* and 35μL (Animals) are required.
* It is not often phenomenon but, reanalysis might be required depending on samples such as a chyle sample. We recommend you to send us ≧100μL (Human) for such requirement if possible. We do not charge for the sample failed to be analyzed due to deficiency of actual sample volume for reanalysis.
Which field it is mainly used for?
✔ Evaluation and Monitoring
✔ Clinical Trials
✔ Clinical Research
What is the Price?
Quotation will be made based on the following 4 service plans.
76101 LipoSEARCH (only 4M classes)
76102 LipoSEARCH (4+20 classes)
76103 LipoSEARCH (4+20 classes)/PN
76106 Others (e.g. Raw Data)
How can I order for it?
Please contact us: do-lipo@ibl-japan.co.jp
Your samples have to be shipped out to LipoSEARCH lab located in Japan.
Click Here to Learn More(External Website)
Why LipoSEARCH?
LipoSEARCH - Reference List
LipoSEARCH - Presentation
LipoSEARCH - New Publication (Comparison between GP
HPLC and NMR)
Contact Us
References
References
- Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia. Fukami H et al. Cell Rep Med. 2021 Nov 16;2(11):100446.PMID: 34841293
- Distinct Differences in Lipoprotein Particle Number Evaluation between GP-HPLC and NMR: Analysis in Dyslipidemic Patients Administered a Selective PPARα Modulator, Pemafibrate. Yamashita S et al. J Atheroscler Thromb
. 2021 Feb 2.PMID: 33536398 - Administration of eicosapentaenoic acid may alter lipoprotein particle heterogeneity in statin-treated patients with stable coronary artery disease: A pilot 6-month randomized study. Tani S et al. J Cardiol. 2020 Nov;76(5):487-498.PMID: 32636128
- Evolocumab Effects on Lipoproteins, Measured by High-Performance Liquid Chromatography. Masuda D et al. J Atheroscler Thromb. 2020 Nov 1;27(11):1183-1207.PMID: 32435010
- VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction. Usui N et al. EBioMedicine. 2020 Aug;58:102917.PMID: 32739868
- Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. Iwaki A. et al. FASEB J. 2020 Jul;34(7):9450-9465.PMID: 32496646
- Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice. Chikada H et al. Sci Rep. 2020 Jun 16;10(1):9704.PMID: 32546802
- Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression by decreasing inflammatory cells in a murine model of atherosclerosis. Sato Y et al. Int J Cardiol Heart Vasc. 2020 May 10;28:100529.PMID: 32577494
- Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT. Sato H et al. Cell Rep. 2020 May 5;31(5):107579.PMID: 32375030
- Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis. Reisman SA et al. J Biochem Mol Toxicol. 2020 May 14;e22526.PMID: 32410268
- Umbilical cord blood stearoyl-CoA desaturase index and lipoprotein lipase mass level in small-for-gestational age newborns. Fuwa K et al. Prostaglandins Leukot Essent Fatty Acids. 2020 May;156:102028.PMID: 31744651
- D-Allulose enhances uptake of HDL-cholesterol into rat's primary hepatocyte via SR-B1. Kanasaki A et al. Cytotechnology. 2020 Apr;72(2):295-301.PMID: 32086695
- Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice. Arai C et al. Nutr Metab (Lond). 2020 Mar 18;17:22.PMID: 32206077
- A 6-month systems toxicology inhalation study in ApoE -/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke. Szostak J et al. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H604-H631.PMID: 31975625
- Sesame lignans reduce LDL oxidative susceptibility by downregulating the platelet-activating factor acetylhydrolase. Nakamura Y et al. Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2151-2161.PMID: 32141585
- MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo. Meng X et al. Cardiovasc Drugs Ther. 2020 Feb;34(1):25-39.PMID: 32034643
- The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice. Ohshiro T et al. Biol Pharm Bull. 2020;43(6):951-958.PMID: 32475917
- β-Aminoisobutyric Acid Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice. Shimba Y et al. Biol Pharm Bull. 2020;43(6):1016-1019.PMID: 32475911
- Red Clover (Trifolium pratense L.) Sprout Prevents Metabolic Syndrome. Yokoyama S et al. J Nutr Sci Vitaminol (Tokyo). 2020;66(1):48-53.PMID: 32115453
- Omega-3 fatty acid ethyl esters improve low-density lipoprotein subclasses without increasing low-density lipoprotein-cholesterol levels: A phase 4, randomized study. Masuda D et al. Atherosclerosis. 2020 Jan;292:163-170.PMID: 31809985
- Lipoprotein profile and lipid metabolism of PXB-cells ®, human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs. Hata K et al. Biomed Res. 2020;41(1):33-42.PMID: 32092738
- Dissimilar Effects of Anagliptin and Sitagliptin on Lipoprotein Subclass in Standard or Strong Statin-Treated Patients with Type-2 Diabetes Mellitus: A Subanalysis of the REASON (Randomized Evaluation of Anagliptin versus Sitagliptin on Low-Density LipoproteiN Cholesterol in Diabetes) Trial. Hirai H et al. J Clin Med. 2019 Dec 30;9(1):93.PMID: 31905896
- Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation. Ishimaru K et al. Sci Rep. 2019 Dec 4;9(1):18329.PMID: 31797978
- Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination. Yamashita S et al. Int J Mol Sci. 2019 Nov 6;20(22):5537.PMID: 31698825
- A low-carbohydrate ketogenic diet promotes ganglioside synthesis via the transcriptional regulation of ganglioside metabolism-related genes. Okuda T. Sci Rep. 2019 May 20;9(1):7627.PMID: 31110277
- N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 diabetes and hypertriglyceridemia: a pilot study. Ide K et al. Lipids Health Dis. 2018 Mar 15;17(1):51.PMID: 29544483
- Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice. Amano A et al. Arch Biochem Biophys. 2017 May 15;622:47-58.PMID: 28341248
- Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial. Ishibashi S et al. Atherosclerosis. 2016 Jun;249:36-43.PMID: 27062408
- Recent Advances in Analytical Methods on Lipoprotein Subclasses: Calculation of Particle Numbers from Lipid Levels by Gel Permeation HPLC Using "Spherical Particle Model". Okazaki M et al. J Oleo Sci. 2016;65(4):265-82.PMID: 27041512
- Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency. Kuroda M et al. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1756-62.PMID: 24876348
- Serum cholesterol and triglyceride reference ranges of twenty lipoprotein subclasses for healthy Japanese men and women. Furusyo N et al. Atherosclerosis. 2013 Dec;231(2):238-45.PMID: 24267234
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov
FAQ
FAQ
-
Q.Does the method have any correlation with existing standard method?
-
A.The method is correlated with ultracentrifugation method.
-
Q.How samples should be stored until the shipping?
-
A.Please keep samples at -80C. Although one freeze-thaw cycle is acceptable, the repeated cycles will affect the data.
-
Q.Does hemolysis affect the results?
-
A.A clear peak appears for hemolysis after HDL and the peak usually does not affect the calculation of HDL data.
-
Q.Is there any requirement for feeding animals or subjects?
-
A.The method has no particular requirement for the way of feeding. It depends on the study.
-
Q.Is there any validation data such as CV data and reproducibility?
-
A.Various validation data are available.
-
Q.Can you provide the fraction of lipoprotein?
-
A.Unfortunately, it cannot be provided. LipoSEARCH is a HPLC based lipoprotein analyzing service for providing the concentration, size of 4 major classes and its sub-classes in details through the process of lipoprotein separation and enzymatic reaction by a post column. We do not provide any services for separating and collecting lipoprotein.
-
Q.What kind of plasma sample can be used?
-
A.Any plasma samples (EDTA-plasma, citrate-plasma and heparin-plasma) which are collected by blood collection tubes coated anticoagulants can be used.
However, postheparin plasma (intravenous heparin) cannot be used. -
Q.Is cell culture supernatant applicable for analysis by LipoSEARCH?
-
A.Yes. The volume is required more than 250µL for the analysis.
-
Q.Is it possible to analyze cell culture supernatants in 96-well plates?
-
A.No it is not applicable. Please prepare your samples in micro tubes.
-
Q.Can samples derived from genetically modified cells be analyzed by LipoSEARCH?
-
A.No. Such samples (including virus-infected cells) are not acceptable.
-
Q.Can samples inactivated by surfactants be analyzed by LipoSEARCH?
-
A.No. because it is difficult to obtain accurate data with the samples containing surfactants.
There is also a risk for damaging the analytical system if we run the system with such samples.