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#28135 Anti- OPRT Rabbit IgG Affinity Purify

  • WB
  • Breast Cancer
  • Lung SCC
  • Gastric Cancer
  • Large Intestine Cancer
Intended Use：
Research reagents
Application：
WB, IHC
Package Size1：
100 μg
Package Size2：
10 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 28135
Product Name Anti- OPRT Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, IHC
Immunizing antigen Synthetic peptide of a part of Human OPRT(ISAADRLEAAEMYRKAAWEAY: 454-474)
Purification Method Purified with antigen peptide
Package Form Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Thymidylate synthase/TS (EC 2.1.1.45), Dihydropyrimidine degydrogenase/DPD (EC 1.3.1.2), Thymidene phosphorylase/TP (EC 2.4.2.4) and Orate phosphorybosyl transferase/OPRT (EC 2.4.2.10) are known as key enzymes related to nucleic-acid metabolism within the body. These enzymes are also known to be related to activation, metabolism and catabolism of 5-FU (5-fluorouracil) which is a metabolic antagonist being widely used for solid cancers including digestive system cancer and breast cancer as an anticancer drug. And there are some reports regarding correlation between the enzymes and the effects of 5-FU-based anticancer drugs. Additionally, TS and DPD have been reported to be prognostification-related factors of individuals who suffer cancers. As seen above, this antibody is useful for researches of nucleic acid and expression of those proteins in cancer tissues including effect prediction of 5-FU-based anticancer drugs and searching for prognostification factors.
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