#28133 Anti-Human APP770 (351) Rabbit IgG Affinity Purify

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Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 100μg

Package Size2：: 10μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	28133
Product Name	Anti-Human APP770 (351) Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB, IHC
Species	Human
Immunizing antigen	Synthetic peptide of a part of human APP770 (KTTQEPLARDPVKL)
Purification Method	Purified with antigen peptide
Package Form	Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100μg
Package Size 2	10μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Alzheimer's disease (AD) is a typical senile dementia and it is believed that accumulation of Amyloidβ (Aβ) in brain parenchyma is a major cause of the disease. Meanwhile, accumulation of Aβ has been also observed on cerebrovascular walls of nearly 90% of individuals suffering with AD. Aβ is known to be produced from Amyloid Precursor Protein (APP) by cleavage with two types of protease (β- and γ- secretase) and Aβ molecules which accumulate in brain parenchyma are mainly produced from APP expressed in neurons, APP695. In contrast to this, another different APP, APP770, was found to be expressed in cerebrovascular endothelial cells, and it has been newly reported that the Aβ produced from the APP770 can accumulate on cerebrovascular walls. This antibody recognizes human APP770.

FAQ

Q.Is endogenic peroxidase treatment required for fluorescence stain?
A.No, it is not required.
Q.Regarding formic acid treatment, is inactivation treatment by citric acid autoclave required?
A.No, inactivation treatment by citric acid autoclave is not required. However, we recommend formic acid treatment (after deparaffinization, leave it in formic acid for 5 to 30 minutes and wash it by running water.) if you use brain tissue.