#28111 Anti- Dock6 Rabbit IgG Affinity Purify

Small GTPase of Rho family is one of signaling factors which control alteration of cellular morphology, cell division and differentiation, and plays an important role in regulation of generation and organogenesis at an individual level. Its functions are strictly regulated and its dysfunction causes many diseases such as immunological disease or neurodegenerative disease. Dedicator of cytokinesis (Dock) 6 is a Rho family small GTPase activating factor (or exchange factor) activating Rac1 and Cdc42 specifically of the Rho family small GTPase, and is widely expressed molecule. It is noted that Dock6 is an important factor for proliferation and differentiation of neurocytes since it is more expressed especially in brain and sensory nerve tissues. Additionally, it is known as a responsible gene for Adams-Oliver syndrome, in which disorders of delivery and sexual differentiation are observed, and which is associated with metabolic disorder and intelligence disorder. It has been reported that mutations in Dock6 cause decline of its function and lead to abnormal cytoskeleton organization. There are proteins, called Dock7 and Dock8, very similar to Dock6 in human but there are still many unclear points about their regulation systems.