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#28073 Anti-Human C4.4A (301) Rabbit IgG Affinity Purify

  • WB
  • Human Skin, Photo of IHC staining is kindly provided by Dr. Michael Ploug, Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark.
Intended Use：
Research reagents
Application：
WB, IHC
Package Size1：
50 μg
Package Size2：
5 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 28073
Product Name Anti-Human C4.4A (301) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, IHC
Species Human
Immunizing antigen Synthetic peptide of a part of Human C4.4A (aghqdrsnsg qypakg).
Purification Method Purified with antigen peptide
Package Form Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 50 μg
Package Size 2 5 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

C4.4A is known to be present in the placenta, skin, esophagus and peripheral mononuclear cells in humans. It is a GPI (glycosylphosphatidylinoditol) binding protein which has a similar structure to urokinase receptor (uPAR) and belongs to Ly-6 family as uPAR. While most of Ly-6 family molecules are consisted of single domain, uPAR is of three cysteine-rich domains. C4.4A is a membrane protein which binds to cell membrane in GPI binding site, and is consisted of two cysteine-rich domains and a cysteine lacking third domain. C4.4A was isolated from metastatic rat pancreatic cancer cell lines in 1989, and its human homolog was isolated in 2001. In human malignant tumors, it has been reported that C4.4A is expressed in malignant melanoma, urothelial, lung, esophageal and colon cancer. It is considered that C4.4A mediates invasion and metastasis of cancer cells by binding with laminin and degrading extracellular matrix in the progress of cancer. Therefore, immunological detection of C4.4A in cancerous tissue is expected to be an indicator of tumor metastasis.
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