#28057 Anti-Human Dock7 Rabbit IgG Affinity Purify

Small GTPase of Rho family is one of signaling factors which control alteration of cellular morphology, cell division and differentiation, and plays an important role in regulation of generation and organogenesis at an individual level. Its functions are strictly regulated and its dysfunction causes many diseases such as immunological disease or neurodegenerative disease.　Dedicator of cytokinesis (Dock) 7 is a Rho family small GTPase activating factor (or exchange factor) activating Ras and Cdc42 specifically of the Rho family small GTPase, and is widely expressed molecule. It is noted that Dock7 is an important factor for proliferation and differentiation of neurocytes or glial cells since it is more expressed especially in both of the central and peripheral nerve tissues. Meanwhile, it is known that Dock7 makes a complex with products of responsible gene for tuberous sclerosis (Plingle disease), TSC1/2, therefore it is suggested that the relation with intellectual decline caused by brain tumor or vascular fibroma of the vessels where much TSC1/2 are expressed. There are proteins, called Dock6 and Dock8, very similar to Dock7 in human, however, their regulation systems are unknown yet.