Product Search

#18975 Anti- Rab27A/B Rabbit IgG Affinity Purify

References (0)
FAQ (0)
Related Materials (0)
Related Products (0)

References (0)
FAQ (0)
Related Materials (0)
Related Products (0)

Intended Use：: Research reagents

Application：: WB

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	18975
Product Name	Anti- Rab27A/B Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB
Immunizing antigen	Recombinant Rab27B protein
Purification Method	Affinity Purified with antigen protein
Specificity	Cross-react with mouse and rat Rab27A/B Not cross-react with the Rab3 subfamily
Package Form	Lyophilized product from 1% BSA in PBS containing 0.05%NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Small-G-protein Rab is a regulator of membrane transport, and is highly conserved and ubiquitously expressed in all eukaryotes. More than 60 Rab isoforms have been reported in humans, and they are thought to be involved in the transport of various organelles. The Rab27 subfamily is very similar to the Rab3 subfamily, and the Rab27 isoforms Rab27A and Rab27B are expressed in humans and the mouse. A mutation of the Rab27A gene causes a hereditary disease in humans, called Griscelli syndrome which is manifested by pigment anomalies and impaired immunity. Activated GTP-Rab27A is involved in the melanosome transport and the release of a variety of secretory granules, by binding to a specific effector molecule (e.g., synaptotagmin-like protein (Slp), Slac2). Rab27B, as well as Rab27A, is expressed on the surface of secretory granules and is known to be involved in amylase secretion by the parotid gland.