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#18953 Anti-Human Olig2 Rabbit IgG Affinity Purify
- Intended Use:
- Research reagents
- Application:
- WB, IHC
- Package Size1:
- 100 μg
- Package Size2:
- 10 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IHC:Immunohistochemistry
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 18953 |
---|---|
Product Name | Anti-Human Olig2 Rabbit IgG Affinity Purify |
Intended Use | Research reagents |
Application | WB, IHC |
Species | Human |
Immunizing antigen | Synthetic peptide of a C-terminal part of Human Olig2(CMGAGSLPRLTSDAK) |
Purification Method | Purified with antigen peptide |
Specificity | Cross-reacts with mouse and rat |
Package Form | Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 μg |
Package Size 2 | 10 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
Oligodendorocytes are defined as the glial cells of the central nervous system that make and maintain myelin wrapping around a nerve cell axon. And further, oligodendrocytes are considered as target of some disease such as autoimmune disease and brain tumor. However, there are some problems such that the antibody to oligodendrocytes using in immunostaining has low stability and hardly react oligodendroglioma as tumor of oligodendrocytes. Olig2 is a transcription factor that controls development and differentiation of oligodendrocytes. It is reported that human Olig2 is specifically expressed in both oligodendrocytes and oligodendroglioma.
References
References
- Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice. Isogai E et al. Exp Anim. 2015 Jul 6.PMID: 26156403
- JC virus inclusions in progressive multifocal leukoencephalopathy: scaffolding promyelocytic leukemia nuclear bodies grow with cell cycle transition through an S-to-G2-like state in enlarging oligodendrocyte nuclei. Shishido-Hara Y et al. J Neuropathol Exp Neurol. 2014 May;73(5):442-53.PMID: 24709678
- Findings from positron emission tomography and genetic analyses for cerebellar liponeurocytoma Takami H et al. Brain Tumor Pathol. 2014 Dec 20.PMID: 25527206
- Fluoxetine-Induced Cortical Adult Neurogenesis Ohira K et al. Neuropsychopharmacology. 2013 May;38(6):909-20.PMID: 23303069
- ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination. Ishii A et. al. J Neurosci. 2012 Jun 27;32(26):8855-64.PMID: 22745486
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov