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#18801 Anti-Mouse Claudin-12 (C) Rabbit IgG Affinity Purify

  • WB
  • Claudins C: Crypt V: villus
  • Occludin
  • Merge 30μm
Intended Use：
Research reagents
Application：
WB, IHC, ICC
Package Size1：
100 μg
Package Size2：
10 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry
ICC:Immunocytochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 18801
Product Name Anti-Mouse Claudin-12 (C) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, IHC, ICC
Species Mouse
Immunizing antigen Synthetic peptide of the C terminal part of Mouse Claudin-12(GMHTYSQPYSSRSRLSAI)
Purification Method Purified with antigen peptide
Specificity Claudin-12 specific.
Not cross-react with Claudin-1, -2, -3, -4, -5, -6, -7, -8 and 15.
(Confirmed by western blotting using each transfectant.)
Package Form Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Claudin is a transmembrane protein that 4 times goes through the membrane to be formed a gene family and a tight junction molecule that is involved in cell to cell adhesion of epithelial and endothelial cell sheets. It also gets together among several different and/or same type of Claudin. The structure consists of 2 loops that are found in extracellular and both its N-terminal and C-terminal domain in intracellular.
Fundamental structures among its family are common and its molecular weight is around 20 - 27kDa. Its C-terminal domain binds PDZ domain of ZO-1, ZO-2 and ZO-3 (protein behind the transmenbrane).
It has been known that Claudin-1, 2, 6, 7 and 15 are distributed in mouse liver and kidneys while Claucin-5 is in vascular endothelium.
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