#18571 Anti-Human N-Cadherin (YS) Rabbit IgG Affinity Purify

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Intended Use：: Research reagents

Application：: WB, IP, IHC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	18571
Product Name	Anti-Human N-Cadherin (YS) Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB, IP, IHC
Species	Human
Immunizing antigen	Recombinant human N-Cadherin extracellular subdomain 1-3
Purification Method	Purified with antigen peptide
Specificity	Not cross-react with other Cadherin’s transfectants.
Package Form	Lyophilized product from 1% BSA in PBS containing 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Cadherins are a family of Ca2+-dependent intercellular adhesion molecules.　They play an important role in cell-cell interaction, histogenesis and cellular transformation, and association with the actin cytoskeleton regulates their function by a complex of cytoplasmic proteins called the catenins (α, β, γ). Among the cadherin protein family, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of β-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.