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#10401 Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb

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Intended Use：: Research reagents

Application：: WB, IP, FCM

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; FCM:Flow Cytometry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10401
Product Name	Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb
Intended Use	Research reagents
Application	WB, IP, FCM
Species	Mouse
Immunizing antigen	Recombinant protein of mouse c-MPL extracellular domain
Source	Mouse-Rat hybridoma　(P3X63-Ag.8.653 × Wistar rat spleen cells, supernatant)
Clone Name	AMM2
Subclass	IgG1
Purification Method	Affinity purified with Protein G
Specificity	Reacts with mouse c-MPL/TPOR.
Package Form	Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Thrombopoietin promotes the growth and differentiation (proliferation) of megakaryocytes which produce platelets. TPOR (Thrombopoietin receptor), which is also called c-MPL (Myeloproliferative leukemia protein) or CD110, is a receptor for thrombopoietin. And it is suggested that TPOR may also play a role in the maintenance of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, megakaryocytes and platelets. This receptor is activated when thrombopoietin protein binds to it, and the activated receptor stimulates a signaling pathway called the JAK/STAT pathway, which transmits signals from outside the cell to the cell's nucleus and is important for controlling the production of blood cells. This antibody specifically reacts with mouse c-MPL/TPOR protein. *As this product contains NaN3, customized form is required for neutralization test. Please feel free to contact us for quotation for the customized form if you intend to conduct neutralization test.