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- #10377 Anti-Human RGMa (410-10) Mouse IgG MoAb
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#10377 Anti-Human RGMa (410-10) Mouse IgG MoAb
- Intended Use:
- Research reagents
- Application:
- WB, IP, FCM
- Package Size1:
- 100 μg
- Package Size2:
- 10 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IP:Immunoprecipitation
- FCM:Flow Cytometry
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 10377 |
---|---|
Product Name | Anti-Human RGMa (410-10) Mouse IgG MoAb |
Intended Use | Research reagents |
Application | WB, IP, FCM |
Species | Human |
Immunizing antigen | Synthetic peptide of a part of Human RGMa (LYERTRDLPGRAAAGL) |
Source | Mouse-Mouse hybridoma (X63 - Ag 8.653 × BALB/c mouse spleen cells, supernatant) |
Clone Name | 410-10 |
Subclass | IgG2b |
Purification Method | Affinity purified with Protein A |
Package Form | Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 μg |
Package Size 2 | 10 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
RGMa (Repulsive Guidance Molecule a) is a GIP-anchored protein, about 33 kDa, and it is implicated in axonal guidance and neural tube closure of embryonic retina. It has reported as a potent inhibitor of axonal regeneration in the adult central nervous system (CNS). It is speculated that RGMa inhibits neurite outgrowth by activating the RhoA-Rho kinase signaling pathway in vitro. While, it has reported that, in a rat SCI (spinal cord injury) model, neurite outgrowth is enhanced by administration of anti-RGMa antibody to lesion site, resulting they are improved in mortor functional recovery. Thus function analysis of RGMa is attracting attention in a research field of axonal regeneration of CNS. This antibody detects human RGMa and can be used for western blotting, immuno-precipitation and FACS analysis.