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#10375 Anti-Human SP-A (PE10) Mouse IgG MoAb

Intended Use：
Research reagents
Application：
IHC
Package Size1：
500 μg
Package Size2：
50 μg
Note on Application Abbreviations
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10375
Product Name Anti-Human SP-A (PE10) Mouse IgG MoAb
Intended Use Research reagents
Application IHC
Species Human
Immunizing antigen Purified surfactant apoprotein A
Source Mouse-Mouse hybridoma
Clone Name PE10
Subclass IgG2b
Purification Method Affinity purified with Protein A
Package Form Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 500 μg
Package Size 2 50 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Lung surfactant is a lipoprotein complex which is synthesized and secreted into the alveoli of the lung by type II pneumocytes. Its major protein component, surfactant protein-A (SP-A), is a glycoprotein with a reduced denatured molecular mass of 35 kDa, and is a useful immunohistochemical marker for lung adenocarcinoma. The reactivity of PE10 antibody shows that normal type II pneumocytes and pulmonary macrophages are positive for SP-A in the cytoplasm, whereas type I pneumocytes, bronchial surface epithelial cells and bronchial gland cells are devoid of immunoreactivity. Immunoreactivity for SP-A is also seen in reactive hyperplastic type II pneumocytes, and is stronger in the hyperplastic type II pneumocytes than in normal type II pneumocytes. In primary lung adenocarcinoma, the expression of SP-A is almost the same for the various adenocarcinomas classified by the grade of histological differentiation.
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