#10351F Anti-Human PDGFRβ (22B1) Mouse IgG MoAb (Frozen)

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Intended Use：: Research reagents

Application：: WB, IP, FCM, NT

Package Size1：: 100 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; FCM:Flow Cytometry; NT:Neutralization Test

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10351F
Product Name	Anti-Human PDGFRβ (22B1) Mouse IgG MoAb (Frozen)
Intended Use	Research reagents
Application	WB, IP, FCM, NT
Species	Human
Immunizing antigen	Recombinant protein of extracellular domain of human PDGFRβ
Source	Mouse-Mouse hybridoma　(X63-Ag8.653×BALB/c spleen cells)
Clone Name	22B1
Subclass	IgG1
Purification Method	Affinity Purified with protein A
Specificity	Confirmed by western blotting with TIG-7 cell.
Package Form	Frozen product in PBS ( Non-containing BSA and NaN3, sterilized)
Storage Condition	ｰ20℃
Poisonous and Deleterious Substances	Not Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

PDGF, a ligand of PDGFR, has 4 isofoms, A-, B-, C- and D-chains, and forms hetero and/or homo dimers, PDGF-AA, -AB, -BB, -CC, -DD. On the other hand, PDGFR has 2 isoforms, α- and β-chains and forms hetero and/or homo dimers, PDGFR-αα, -αβ and -ββ. PDGF-A and PDGF-C binds specifically to PDGFR-α, PDGF-B binds to PDGFR-α and PDGFR-β, and PDGF-D binds specifically to PDGFR-β. In other words, PDGF-AA and PDGF-CC can activate only PDGF-αα, while PDGF-AB can activate PDGFR-αα and PDGFR-αβ, and PDGF-BB can activate PDGFR-αα, -αβ and -ββ. While, PDGF-DD has been reported to be able to activate PDGFR-αβ as well as PDGFR -ββ. When the receptor is dimerized, tyrosine kinase activity in the intracellular region increases and auto-phosphorylation of the tyrosine residue takes place.