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#10345 Anti-Rat Occludin (1A8) Mouse IgM MoAb

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Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 50 μg

Package Size2：: 5 μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10345
Product Name	Anti-Rat Occludin (1A8) Mouse IgM MoAb
Intended Use	Research reagents
Application	WB, IHC
Species	Rat
Immunizing antigen	Recombinant Rat Occludin
Source	Mouse-Mouse hybridoma　(NS-1 myeloma X Mouse Lymphocytes)
Clone Name	1A8
Subclass	IgM
Purification Method	Affinity purified with anti-mouse IgM
Specificity	Cross-reacts with human and dog
Package Form	Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	50 μg
Package Size 2	5 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Occludin is an approximately 60kDa-integral membrane protein localizing at Tight-Junction, and composed of short N-terminal cytosolic domain, four transmembrane domains and long C-terminal cytosolic domain. It is reported that Occludin has no homology to claudin family and forms strand by coporimerization with claudin family proteins. It is considered that Tight-Junction plays an important role in maintenance of cellular polarity (fence function) and in regulating the passage of ions and small molecular through the paracellular pathway (barrier function).