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#10141 Anti-Human CIS3/SOCS-3 (19A5) Mouse IgG MoAb

  • WB
Intended Use：
Research reagents
Application：
WB
Package Size1：
200 μg
Package Size2：
20 μg
Note on Application Abbreviations
WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10141
Product Name Anti-Human CIS3/SOCS-3 (19A5) Mouse IgG MoAb
Intended Use Research reagents
Application WB
Species Human
Immunizing antigen Synthetic peptide of the C-terminal part of human CIS3/SOCS-3
Source Mouse-Mouse hybridoma　(X63 - Ag 8.653 × BALB/c mouse spleen cells, supernatant)
Clone Name 19A5
Subclass IgG1
Purification Method Affinity purified with antigen peptide
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 200 μg
Package Size 2 20 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BF-ER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPO-dependent proliferation and STAT5 activation. It is reported that JAB/SOCS-1 is strongly induced by interferon-gamma and forced expression of JAB/SOCS-1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS-1 knockout mice revealed that JAB/SOCS-1 is indeed a 'negative feedback regulator' that determine the sensitivity of cells to IFN gamma.
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