IBL News

IBL products introduced in this IBL news are applicable for research use only and cannot be used for diagnostic or medical purposes.
 
We are pleased to introduce an article that investigates the association between serum Klotho levels and frailty based on data from the U.S. National Health and Nutrition Examination Survey (NHANES).
 
For details, please refer to the original research article below.
Frailty is characterized as a state of decreased muscle strength and psychosomatic activity due to aging, and its diagnosis and prevention are extremely important for extending the healthy life of the elderly.
 
The U.S. National Health and Nutrition Examination Survey (NHANES) is a biennial survey conducted by the Centers for Disease Control and Prevention (CDC) to assess the health and nutritional status of the American population. During this survey, serum Klotho levels were measured in blood samples collected from 2007 to 2016.
 
This article examines the association between serum Klotho levels and the Frailty Index, which is calculated from 53 survey items, using data from 9,597 individuals aged 40 to 79 years in NHANES.
 
A multivariate logistic regression model* was used in the analysis. The results revealed an inverse and linear association between serum Klotho levels and Frailty Index, suggesting that higher serum Klotho levels are correlated with a lower risk of frailty. This association was found to be more pronounced in those under 65 years of age and with a BMI of 25 kg/m2 or greater. On the other hand, no significant associations were observed for race, gender, and comorbidities.
 
From these results, the authors concluded that the mechanisms underlying aging and frailty need to be further investigated.
 
*Multivariate logistic regression model: a statistical method of multivariate analysis that explains and predicts the probability of a binary outcome occurring from several factors.
 
We offer a wide variety of kits for the determination of α-Klotho. Click here for more details.
We hope this information will be useful for your research.
 
Keywords: α-Klotho, Alpha Klotho, FGF23, Kidney disease, Chronic Kidney disease (CKD), Mineral Bone Disease (MBD), Osteoporosis, Aging, Alzheimer's Disease
 
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Antibody related Business Division
Immuno-Biological Laboratories Co., Ltd.
Email: do-ibl@ibl-japan.co.jp
 

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