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Any IBL product introduced in this IBL news is applicable for research use only and it cannot be used for diagnosis or medical purpose.

Sadamu Homma, MD, PhD, Division of Oncology, Research Center for Medical Sciences, Jikei University School of Medicine (Tokyo, JAPAN), et al reveled in a recent study that assessed retrospectively blood soluble OX40 (sOX40) levels in patients (N=22) with advanced colorectal cancer (CRC), that 1) sOX40 levels were significantly higher compared with healthy adults, 2) sOX40 levels were positively correlated with blood levels of tumor biomarkers (CA 19-9, CEA), blood levels of CRP and soluble PDL-1, and negatively correlated with that of Alubmin, and notably 3) high blood sOX40 levels correlated with a reduced survival time. 

Sawada R et al. High blood levels of soluble OX40 (CD134), an immune costimulatory molecule, indicate reduced survival in patients with advanced colorectal cancer. Oncol Rep. 2019 Sep 6.

(Background)　
The interaction between OX40 on T cells and the OX40L on Antigen-presenting cells is a crucial step for T-cell activation and the promotion of antitumor immunity. So far preclinical studies revealed that the stimulation of OX40 using an agonistic anti-OX40 antibody or OX40L/Ig fusion protein bring about antitumor activity.

On the other hand, how sOX40 exist in blood in advanced cancer patients and its clinical significance were so far unknown.
 
In the clinical settings, it is known that the immune status in the tumor microenvironment as well as infiltrating lymphocytes are both crucial factors that have  impacts on tumor growth, metastasis, and its chemoresistance. A new anti cancer drug targeting PD-1/PD-L1 have appeared and drawing wide attentions. It is of interest that this report revealed that high blood sOX40 levels correlated with a reduced survival in patient with advanced CRC, considering that its cell bound OX40 is a contributor of T-cell activation by an another pathway from PD-1/PD-L1.
 
#27110 Human CD134/OX40 Assay Kit - IBL was used in this study.

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