IBL News

#27705 Mouse/Rat Total Insulin (high sensitivity) Assay Kit - IBL has been released. It has been recognized that it is important to measure insulin in plasma of rodent in non-clinical test of drug development of type 2 diabetes.

Measuring insulin in fasting (F-IRI) for calculation of HOMA-R that is a marker of insulin resistance is especially critical, however it was difficult to measure F-IRI in normal rat and mouse samples that is very low concentration by existing commercially available assay kit.

This assay kit consists of 2 specific monoclonal antibodies (clone: 13G4 and 26B2) that were obtained using antibody maturation technique (ref.1) and we have achieved to develop the kit with 10 to 20 times higher sensitivity than currently available commercial kits. The assay kit can measure total insulin less than 0.1ng/mL in normal mouse and rat samples in fasting because of the superior sensitivity.