ELISA

Inflammatory Diseases Cancers, Arthritis, Hepatitis, etc.

IBL has been continuously involved in the research, development, manufacturing, and supply of antibodies used in cancer research since we first started research and development on Carcinoembryonic antigen (CEA) when the company was established. We have various antibodies and ELISAs which can be used in research of various cancers, such as large intestine cancer, stomach cancer, thyroid cancer, breast cancer, lung cancer, liver cancer, prostate cancer, leukemia, and mesothelial tumors.

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Made in Japan Quality

IBL has maintained ISO13485 certification since 2009. All our antibodies and ELISA products are manufactured and controlled in-house at our head office and main laboratory located in Japan. We are proud and confident in the quality of our products and services.

IBL carefully conducts all processes of antibody development with the utmost attention to the process of selecting sequence, immunization, screening, and cloning to find the best antibodies for a particular purpose. Our mission is to consistently supply quality products that are both highly specific and sensitive.

CD134/OX40

Factors involved in activated T cells and T cell proliferation /invasion

CD134/OX40 is a receptor of OX40 ligand (OX40L) transactivated by Tax of HTLV-1. OX40 is expressed in activated CD4+ and CD8+ T cells. OX40 on the activated T cells has a role in proliferation of T cells and production of cytokines by binding with OX40L expressed on antigen presenting cells like dendritic cells or activated B cells. In addition, it may also be involved in activated T cell invasion to inflamed areas through the binding with OX40L.

CD134/OX40

#27110 h_CD134/OX40

LRG

Measurement of the Concentration of LRG
in Blood of Arthritis Evoked Mice

LRG is focused on as an active biomarker used in research of inflammatory related disease. It has been used in research of various cancers and inflammatory disease such as idiopathic Normal Pressure Hydrocephalus (iNPH), diabetes, pancreatic cancer and Primary Biliary Cholangitis (PBC).

LRG

Mac-2bp

Explanation of Method of Feeding

Normal Meal
The meal that is used as a normal meal at an animal testing center was fed to mice.

NASH Meal
High fat and high cholesterol food (7.5% fatty acid, 1.25% cholesterol, and 0.5% cholic acid) was fed to mice for 4 weeks or 8 weeks.

Mac-2 binding protein (Mac-2bp) is a secreted glycoprotein (90kDa) and identified as a ligand of Galectin-3. It is considered that it promotes cell adhesion through interaction with Galectin-3. It has also been considered that Mac-2bp is a useful blood biomarker for research of chronic hepatic diseases such as NASH (Non-Alcoholic Steatohepatitis).